Rationally designed, synthetic antibody libraries and uses therefor
US11008568B2 · kind B2 · utility
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169References
17Claims
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Key dates
| Filing date | Dec 28, 2018 |
| Grant date | May 18, 2021 |
| Priority date | — |
| Expiry date | Feb 5, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B50/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.