Methods for predicting prostate cancer relapse

US11008624B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Jianhua Luo · Wexford, US
• Yanping Yu · Wexford, US
• Chien-Cheng Tseng · Pittsburgh, US
• Shuchang Liu · Pittsburgh, US
• George Konstantine Michalopoulos · Pittsburgh, US
• Joel B. Nelson · Pittsburgh, US

Key dates

• Filing date: Feb 7, 2018
• Grant date: May 18, 2021
• Expiry date: May 12, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for determining whether a subject having prostate cancer is at an increased risk for relapse or rapid relapse. It is based, at least in part, on the results of a comprehensive genome analysis of 273 prostate cancer samples, which indicate that the percentage of large size CNVs predicts prostate cancer relapse. In certain embodiments, a method for determining whether a prostate cancer patient has an increased risk of suffering a relapse or a rapid relapse comprises determining the number and size of CNVs in a sample and determining a large size ratio, where if the large size ratio exceeds a particular threshold, the patient is deemed to be at an increased risk for relapse or rapid relapse.