Lipids and lipid compositions for the delivery of active agents

US11013696B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Luis Brito · Cambridge, US
• Delai Chen · Cambridge, US
• Gabriel Grant Gamber · Cambridge, US
• Andrew Geall · Littleton, US
• Kevin Love · Somerville, US
• Thomas Zabawa · Boston, US
• Frederic Zecri · Cambridge, US

Key dates

• Filing date: Aug 12, 2019
• Grant date: May 25, 2021
• Expiry date: Aug 27, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/00071
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.