Substituted pyridinone-containing trycyclic compounds, and methods using same

US11013726B2 · kind B2 · utility

Assignee

• ARBUTUS BIOPHARMA CORPORATION · CA

Inventors

• Laurèn Danielle Bailey · Hatboro, US
• Yingzhi Bi · Plainsboro, US
• Shuai Chen · Warrington, US
• Bruce D. Dorsey · Ambler, US
• Dimitar B. Gotchev · King of Prussia, US
• Richard J. Holland · Vancouver, CA
• Ramesh Kakarla · Doylestown, US
• Duyan Nguyen · North Wales, US
• Mark Wood · Port Moody, CA

Key dates

• Filing date: Mar 30, 2020
• Grant date: May 25, 2021
• Expiry date: Mar 30, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.