TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements

US11013909B2 · kind B2 · utility

Assignee

• Novocure GMBH · CH

Inventors

• Cornelia Wenger · Ericeira, PT
• Pedro Michael Cavaleiro Miranda · Lisbon, PT
• Zeev Bomzon · Kiryat Tivon, IL
• Noa URMAN · Haifa, IL
• Eilon Kirson · Ramat HaSharon, IL
• Yoram Wasserman · Haifa, IL
• Yoram Palti · Haifa, IL

Key dates

• Filing date: Dec 17, 2018
• Grant date: May 25, 2021
• Expiry date: Mar 9, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G16Z99/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types. A location of the target tissue is identified within the anatomic volume, and the positions for the electrodes are determined based on the 3D map of electrical conductivity and the position of the target tissue.