Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
US11014927B2 · kind B2 · utility
5Cited by
67References
3Claims
0Family size
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Key dates
| Filing date | Mar 20, 2018 |
| Grant date | May 25, 2021 |
| Priority date | — |
| Expiry date | Mar 20, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.