Compositions and methods for altering second messenger signaling

US11014956B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center; The Rockefeller · US
• University; Rutgers, The State University of New Jersey · US
• University of Bonn · DE

Inventors

• Dinshaw J. Patel · New York, US
• Thomas Tuschl · Oettingen, DE
• Manuel Ascano, Jr. · New York, US
• Yang-Chang Wu
• Yizhou Liu · New York, US
• Winfried Barchet · Bonn, DE
• Gunther Hartmann · Munich, DE
• Thomas Zillinger · Bonn, DE
• Roger A. Jones · New Brunswick, US
• Barbara L. Gaffney · Fryeburg, US
• Pu-Xian Gao · Coventry, US

Key dates

• Filing date: Jun 28, 2019
• Grant date: May 25, 2021
• Expiry date: Jun 28, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.