Enzymatic synthesis of L-nucleic acids

US11015178B2 · kind B2 · utility

Assignee

• Aptarion Biotech AG · DE

Inventors

• Andreas Pech · Bodenwerder, DE
• Ralf David · Leipzig, DE
• Florian Jarosch · Berlin, DE
• Michael Jahnz · Berlin, DE
• Sven Klussmann · Berlin, DE

Key dates

• Filing date: Dec 5, 2017
• Grant date: May 25, 2021
• Expiry date: Dec 5, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/07
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention is related to a method for adding one or more L-nucleotides to the 3′ end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising an enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid.