Polynucleotides encoding engineered tyrosine ammonia lyase variants
US11015184B2 · kind B2 · utility
0Cited by
101References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 2019 |
| Grant date | May 25, 2021 |
| Priority date | — |
| Expiry date | Nov 20, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y403/01023
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.