Synthesis and structure of high potency RNA therapeutics

US11015204B2 · kind B2 · utility

Assignee

• ARCTURUS THERAPEUTICS, INC. · US

Inventors

• Pattraranee Limphong · San Diego, US
• Carlos G. Perez-Garcia · San Diego, US
• Kiyoshi Tachikawa · San Diego, US
• Padmanabh Chivukula · San Diego, US
• Arisa Cale · San Diego, US
• Angel I-Jou Leu · San Diego, US
• Jared Davis · Poway, US

Key dates

• Filing date: May 31, 2018
• Grant date: May 25, 2021
• Expiry date: Oct 12, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2015/8518
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.