Methods for determining response to a hypomethylating agent

US11015223B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• DANA-FARBER CANCER INSTITUTE, INC. · US
• THE BRIGHAM AND WOMEN'S HOSPITAT . INC · US

Inventors

• Rafael Bejar · Boston, US
• Benjamin Ebert · Brookline, US
• Donna Neuberg · Brookline, US
• Kristen Stevenson · Waltham, US

Key dates

• Filing date: May 12, 2014
• Grant date: May 25, 2021
• Expiry date: Oct 9, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are methods for predicting a response of a subject with myelodysplastic syndrome to treatment with a hypomethylating agent, for example using a sample obtained from the subject. The methods can be used to select a subject for treatment with a hypomethylating agent, and/or measure a subject's response to therapy and/or disease progression/regression. The methods include detecting, in a nucleic acid sample obtained from a subject, one or more mutations of any one or more genes selected from Table 3a.