Unit structure-type pharmaceutical composition for nucleic acid delivery
US11020418B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 5, 2017 |
| Grant date | Jun 1, 2021 |
| Priority date | — |
| Expiry date | Mar 26, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A unit structure-type pharmaceutical composition includes a single nucleic acid, such as an antisense nucleic acid, electrostatically bound to a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. The negative charges of the nucleic acid are counterbalanced, at least substantially, by the positive charges of the cationic polyamino acid segment such that the pharmaceutical composition is electrically neutral or nearly electrically neutral. Further, the nucleic acid is covered with the hydrophilic polymer chain segment. The block copolymer thereby improves the blood retention capability of the nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.