Patent · US Active

Injectable hydrogels that promote mineralization and afford sustained release of bioactive ions

US11020425B2 · kind B2 · utility

0Cited by

1References

13Claims

0Family size

Assignee

The Chinese University of Hong Kong · CN

Inventors

Liming Bian · Hong Kong, CN
Kunyu Zhang · Hong Kong, CN

Key dates

Filing date	Dec 19, 2017
Grant date	Jun 1, 2021
Priority date	—
Expiry date	Nov 21, 2038

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61L2430/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a hybrid hydrogel stabilized by multivalent cross-linking domains. The hydrogel combines inorganic nanoparticles along with an organic polymer network. The resulting material has reinforced mechanical properties and significant mineralization, and affords sustained long-term release of ions. Furthermore, ions released from the hydrogel can enhance cell spreading and promote the osteogenic differentiation of implanted cells. These promising results indicates that the provided compositions and methods are particularly appealing for bone regenerative applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.