Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof

US11021457B2 · kind B2 · utility

Assignee

• WIGEN BOIMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD. · CN

Inventors

• Zhiyi Yao · Shanghai, CN
• Cheng LUO · Shanghai, CN
• Yuli Xie · Shanghai, CN
• Liyan Yue · Shanghai, CN
• Wei Wan · Shanghai, CN
• Yuanyuan Zhang · Beijing, CN
• Hualiang Jiang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: May 17, 2018
• Grant date: Jun 1, 2021
• Expiry date: Jul 1, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator.