Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors

US11021458B2 · kind B2 · utility

Assignee

• BioCryst Pharmaceuticals, Inc. · US

Inventors

• Pravin L. Kotian · Hoover, US
• Yarlagadda S. Babu · Birmingham, US
• Weihe Zhang · Vestavia Hills, US
• Peng-Cheng Lu · Timonium, US
• Minwan Wu · Vestavia Hills, US
• Wei Lv · Hoover, US
• Trung Xuan Nguyen · Hoover, US
• Zhao Dang · Vestavia Hills, US
• Venkat R. Chintareddy · Vestavia Hills, US
• V. Satish Kumar · Birmingham, US
• Krishnan Raman · Birmingham, US

Key dates

• Filing date: Jul 15, 2019
• Grant date: Jun 1, 2021
• Expiry date: Jul 24, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.