Sulfone pyridine alkyl amide-substituted heteroaryl compounds

US11021462B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Chunjian Liu · Pennington, US
• Michael G. Yang · Narberth, US
• Zili Xiao · Plainsboro, US
• Ling Chen · Shanghai, CN
• Ryan M. Moslin · Princeton, US
• John S. Tokarski · Princeton, US
• David S. Weinstein · Plainsboro, US
• Stephen T. Wrobleski · Whitehouse Station, US

Key dates

• Filing date: Nov 20, 2018
• Grant date: Jun 1, 2021
• Expiry date: Nov 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.