Patent · US Active

1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use

US11021493B2 · kind B2 · utility

0Cited by

3References

33Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Jennifer R. Allen · Newbury Park, US
Matthew P. Bourbeau · Calabasas, US
James Brown · Moorpark, US
Ning Chen · Thousand Oaks, US
Michael J. Frohn · Thousand Oaks, US
Zice Fu · Foster City, US
Longbin Liu · Thousand Oaks, US
Qingyian Liu · Camarillo, US
Liping H. Pettus · Thousand Oaks, US
Wenyuan Qian · Newbury Park, US
Corey REEVES · West Hollywood, US
Aaron C. Siegmund · Ventura, US

Key dates

Filing date	Dec 13, 2017
Grant date	Jun 1, 2021
Priority date	—
Expiry date	Dec 13, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.