Stabilization and isolation of extracellular nucleic acids

US11021733B2 · kind B2 · utility

Assignee

• QIAGEN GmbH · DE

Inventors

• Martin Horlitz · Hilden, DE
• Annabelle Schubert · Hilden, DE
• Markus Sprenger-Haussels · Mettmann, DE

Key dates

• Filing date: Nov 28, 2018
• Grant date: Jun 1, 2021
• Expiry date: Nov 28, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6806
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides methods, compositions and devices for stabilizing the extracellular nucleic acid population in a cell-containing biological sample using an apoptosis inhibitor, preferably a caspase inhibitor, a hypertonic agent and/or a compound according to formula 1 as defined in the claims.