Patent · US Active

MiRNA markers for the diagnosis of osteosarcoma

US11021756B2 · kind B2 · utility

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5Claims

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Inventors

Zuozhang Yang · Longchuan, CN
YA-NI ZHANG · Tianjin, CN
Yihao Yang · Longchuan, CN
Xiaojuan Li · Beijing, CN
Dongqi Li · Longchuan, CN
Junfeng Xia · Longchuan, CN
Su-Chen Li · Longchuan, CN
Zhaoxin Zhang · Longchuan, CN
Huiling Li · Tangxia, CN
Yanjin Chen · Longchuan, CN

Key dates

Filing date	Nov 21, 2016
Grant date	Jun 1, 2021
Priority date	—
Expiry date	Nov 21, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/178
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention discloses the use of miR-4714, miR-4521, and miR-1292 as diagnostic markers for osteosarcoma. High-throughput sequencing and QPCR experiments prove that the levels of miR-4714, miR-4521, and miR-1292 in the blood of normal and osteosarcoma patients are significantly different, and therefore miR-4714, miR-4521, and miR-1292 can be used as a molecular marker for the diagnosis of osteosarcoma for developing products for the diagnosis of osteosarcoma. The diagnostic product has the following advantages: non-invasive, rapid, sensitive, and has broad application prospects in clinical practice.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.