Patent · US Active

Sentinel signal for adaptive retention time in targeted MS methods

US11024495B2 · kind B2 · utility

0Cited by
1References
20Claims
0Family size

Inventor

Key dates

Filing dateFeb 14, 2020
Grant dateJun 1, 2021
Priority date—
Expiry dateFeb 14, 2040

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N30/72
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A plurality of MRM transitions to be used to monitor a sample are received and divided into two or more contiguous groups. At least one sentinel transition is selected in each group that identifies a next group of the two or more contiguous groups that is to be monitored. A first group of the two or more contiguous groups is placed on a duty cycle list of the tandem mass spectrometer. One or more compounds are separated from the sample and ionized, producing an ion beam. A series of MRM transitions read from the duty cycle list are executed on the ion beam by the tandem mass spectrometer. When at least one sentinel transition of the first group is detected, a next group identified by the sentinel transition is placed on the list.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.