Itraconazole analogs and use thereof

US11028078B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Jun O. Liu · Clarksville, US
• Yingjun Li · Baltimore, US
• Kalyan Kumar Pasunooti · Baltimore, US
• Wukun Liu · Baltimore, US
• Wei Shi · 安丰镇, CN
• Ruojing Li · Baltimore, US
• Sarah Head · Baltimore, US

Key dates

• Filing date: Oct 4, 2018
• Grant date: Jun 8, 2021
• Expiry date: Oct 4, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/506
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.