Methods of using 1-O-acetylbritannilatone spiro aryl isoxazoline compounds

US11028102B2 · kind B2 · utility

Assignee

• XI'AN TAIKOMED PHARMACEUTICAL TECHNOLOGY CO., LTD. · CN

Inventors

• Yonghong Tang · Xi'an, CN
• Minghui Chang · Xi'an, CN
• Huafeng Qi · Xi'an, CN
• Chengyuan Liang · Xi'an, CN
• Xingke Ju · Xi'an, CN
• Lei Tian · Batou, CN
• Yuzhi Liu · Xi'an, CN
• Han Li · Xi'an, CN

Key dates

• Filing date: Feb 29, 2020
• Grant date: Jun 8, 2021
• Expiry date: Feb 29, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of inhibiting leukotriene include: administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject, R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.