Patent · US Active

Capping of unprotected amino groups during peptide synthesis

US11028123B2 · kind B2 · utility

0Cited by

3References

21Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Bernd Henkel · Frankfurt am Main, DE
Tobias Metzenthin · Frankfurt, DE
Manfred Gerken · Marburg, DE
Wolfgang Fiedler · Hemsbach, DE

Key dates

Filing date	Apr 10, 2019
Grant date	Jun 8, 2021
Priority date	—
Expiry date	Apr 10, 2039

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino acid building block C-terminally at an unprotected N-terminal amino group of an amino acid chain, wherein at least one coupling cycle comprises a coupling step (a), a capping step (b), and a de-protecting step (c).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.