Patent · US Active

Detection of short homopolymeric repeats

US11028431B2 · kind B2 · utility

0Cited by

1References

13Claims

0Family size

Assignee

BIOCARTIS, NV · BE

Inventors

Bart Claes · Mechelen, BE
Rudi Rossau · Ekeren, BE

Key dates

Filing date	Sep 22, 2016
Grant date	Jun 8, 2021
Priority date	—
Expiry date	Sep 22, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/158
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present application relates to detection of changes in the number of nucleotides in short homopolymeric nucleic acid repeats, in particular in short homopolymeric microsatellites, for example for the purpose of diagnosing microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency in tumors. Accordingly, methods are provided for detecting changes in the number of nucleotides present in short homopolymeric nucleotide repeat sequences as well as kits and cartridges for automated detection of said changes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.