Stabilization of glutamate dehydrogenase in an aqueous solution
US11029312B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 3, 2020 |
| Grant date | Jun 8, 2021 |
| Priority date | — |
| Expiry date | Jan 3, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90616
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An aqueous composition includes (i) glutamate dehydrogenase from a bacterium of the Clostridium genus, (ii) a stabilizing compound that is a carboxylic acid having a carbon-based chain of at least three carbon atoms and comprising at least two —COOH groups, or a salt thereof, and (iii) any of a monosaccharide polyol, disaccharide polyol, or polymeric macromolecule in addition to the glutamate dehydrogenase. A process for stabilizing the glutamate dehydrogenase in order to maintain antigenic properties of the glutamate dehydrogenase includes stabilizing the glutamate dehydrogenase in the aqueous composition and maintaining the antigenic properties of the glutamate dehydrogenase during storage of the aqueous composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.