Methods of treating CYP2D6 alternative metabolizers
US11033631B2 · kind B2 · utility
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2References
9Claims
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Key dates
| Filing date | Jun 9, 2009 |
| Grant date | Jun 15, 2021 |
| Priority date | — |
| Expiry date | Dec 24, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides various methods comprising the administration of a CYP2D6 bioactive drug covalently bound to a water-soluble oligomer. Metabolism of CYP2D6 bioactive drug conjugates is diverted from CYP2D6 to alternative pathways, and the conjugates may therefore be utilized to alleviate the problems associated with interpopulation variation resulting from the genetic polymorphism in the CYP2D6 gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.