Histone acetyltransferase activators and uses thereof

US11034647B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yan Feng · Chengdu, CN
• Mauro Fa · New York, US
• Ottavio Arancio · New York, US
• Shixian Deng · White Plains, US
• Donald W. Landry · New York, US
• Yitshak Francis · New York, US

Key dates

• Filing date: Dec 9, 2019
• Grant date: Jun 15, 2021
• Expiry date: Dec 9, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2814
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.