Patent · US Active

Hybrid ligand, hybrid biomimetic chromedia and preparing method and use thereof

US11034723B2 · kind B2 · utility

0Cited by

3References

15Claims

0Family size

Assignee

ZHEJIANG UNIVERSITY · CN

Inventors

Shanjing Yao · Zhejiang, CN
Dongqiang Lin · Hangzhou City, CN
Qilei ZHANG · Zhejiang, CN
Xujun Zou · Zhejiang, CN
Huili Lu · Shanghai, CN

Key dates

Filing date	Jan 16, 2018
Grant date	Jun 15, 2021
Priority date	—
Expiry date	Oct 7, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/21
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.