Methods to determine KDM1A target engagement and chemoprobes useful therefor
US11034991B2 · kind B2 · utility
1Cited by
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12Claims
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Key dates
| Filing date | Mar 16, 2017 |
| Grant date | Jun 15, 2021 |
| Priority date | — |
| Expiry date | Apr 6, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/58
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to methods to determine KDM1A target engagement and chemoprobes useful therefor. In particular, the invention relates to non-peptidic KDM1A chemoprobes carrying a tag or label that can be used to assess KDM1A target engagement in cells and tissues. These chemoprobes can also be used to identify KDM1A interacting factors and analyze expression levels of KDM1A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.