Hybrid time-resolved and time-shifted spectroscopy for measuring biological analytes
US11035797B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 17, 2019 |
| Grant date | Jun 15, 2021 |
| Priority date | — |
| Expiry date | Dec 17, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/655
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Systems and methods for hybrid time-resolved and time-shifted spectroscopy for measuring biological analytes are disclosed. Exemplary methods include: illuminating an analyte using first light from and excitation source, the first light having a first excitation wavelength; detecting a first spectrum from the analyte illuminated by the first light using a time-resolved spectroscopy technique, the first spectrum including a first Raman signal and fluorescence; illuminating the analyte using second light, the second light having a second excitation wavelength; detecting a second spectrum using a time-resolved spectroscopy technique; illuminating the analyte using third light, the third light having a third excitation wavelength; detecting a third spectrum; recovering the first Raman signal using the first spectrum, the second spectrum, and the third spectrum using an inverse transform; and using the first Raman signal to identify and measure at least one molecule of the analyte using a database of identified Raman signals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.