3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides

US11040035B2 · kind B2 · utility

Assignees

• Bayer Pharma Aktiengesellschaft · DE
• Deutsches Krebsforschungszentrum · DE

Inventors

• Norbert Schmees · Berlin, DE
• Ilona GUTCHER · Berlin, DE
• Horst IRLBACHER · Berlin, DE
• Benjamin Bader · Berlin, DE
• Na Zhao · Miaocheng, CN
• Michael Platten · Heidelberg, DE
• Ulrike Röhn · Berlin, DE
• Ludwig Zorn · Berlin, DE
• Lars Röse · Berlin, DE
• Detlef Stöckigt · Potsdam, DE

Key dates

• Filing date: May 23, 2017
• Grant date: Jun 22, 2021
• Expiry date: Sep 27, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.