Patent · US Active

Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof

US11040952B2 · kind B2 · utility

0Cited by

0References

16Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Youhong Hu · Shanghai, CN
Jianping Zuo · Shanghai, CN
Dong Lu · Miaoli City, TW
Li-Xi Yang · San Francisco, US
Limin Zeng · Beijing, CN
Feifei Liu · Shandong, CN
Yunzhe Zhang · Shanghai, CN
Wuhong Chen · Tangxia, CN
Xiankun Tong · Shanghai, CN

Key dates

Filing date	Feb 10, 2020
Grant date	Jun 22, 2021
Priority date	—
Expiry date	Feb 10, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.