Auxotrophic strains of staphylococcus bacterium
US11041217B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jan 4, 2019 |
| Grant date | Jun 22, 2021 |
| Priority date | — |
| Expiry date | Jan 11, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/45
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (Δalr1Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.