Patent · US Active

Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them

US11045458B2 · kind B2 · utility

0Cited by

0References

28Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Weiping Tang · Nanhu, CN
Ka Yang · Madison, US
Hao Wu · Shanghai, CN

Key dates

Filing date	Jul 22, 2019
Grant date	Jun 29, 2021
Priority date	—
Expiry date	Jul 22, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D401/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.