Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same
US11045544B2 · kind B2 · utility
1Cited by
12References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2017 |
| Grant date | Jun 29, 2021 |
| Priority date | — |
| Expiry date | Mar 20, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In one aspect, the invention provides a method of making a bioactive peptide-bearing antibody, or fragment thereof, comprising (a) engrafting the amino acid sequence of at least one bioactive peptide of interest into (i) at least one of CDR-H1, CDR-H2 or CDR-H3 of a heavy chain variable region comprising one or more chicken framework regions and/or (ii) at least one of CDR-L1, CDR-L2 or CDR-L3 of the light chain variable region comprising one or more chicken framework regions, and (b) determining whether the antibody has substantially the same biological activity as the bioactive peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.