Infusion set with components comprising a polymeric sorbent to reduce the concentration of m-cresol in insulin

US11045601B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Christopher DeMaria · Stow, US
• Daniel M. Hartmann · Arlington, US
• Graham Barry Jones · South Easton, US
• Christopher Kovalchick · Bedford, US
• Sean Matthew PSZENNY · Cambridge, US
• Rhea SIRKAR · Watertown, US
• Monica Rixman Swinney · Medford, US

Key dates

• Filing date: Apr 21, 2017
• Grant date: Jun 29, 2021
• Expiry date: Apr 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K1/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An insulin infusion set (IIS) device with one or more features designed to achieve longevity in a patients continuous subcutaneous insulin infusion (CSII) site viability. One exemplary feature is an adsorbent material configured to adsorb phenolic excipients (e.g., m-cresol or other preservatives) from the insulin formulation. The adsorbent material may be positioned along a fluid pathway specifically designed to increase and/or extend exposure between the insulin formulation and the adsorbent material. Another exemplary feature is a medicament configured to reduce the patients inflammation or slow the progression of the patients inflammatory response. Yet another exemplary feature is a diffusive catheter configured to deliver the insulin formulation in a diffuse manner.