Heteroaryl-substituted triazoles as APJ receptor agonists

US11046680B1 · kind B1 · utility

Assignee

• AMGEN INC. · US

Inventors

• Ning Chen · Thousand Oaks, US
• Xiaoqi Chen · Palo Alto, US
• Yinhong Chen · Hayward, US
• Alan C. Cheng · Cambridge, US
• Richard V. Connors · Mesa, US
• Jeffrey Deignan · San Francisco, US
• Paul John Dransfield · Arlington, US
• Xiaohui Du · Foster City, US
• Zice Fu · Foster City, US
• James S. Harvey · Arlington, US
• Julie Anne Heath · Chico, US
• Lars V. Heumann · Redwood City, US
• Daniel B. Horne · Natick, US
• Jonathan Houze · Cambridge, US
• Matthew R. Kaller · Ventura, US
• Frank Kayser · San Francisco, US
• Aarif Yusuf Khakoo · Woodside, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Julio C. Medina · Redwood City, US
• Jeffrey T. Mihalic · San Francisco, US
• Nobuko Nishimura · Calabasas, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Gayathri Swaminath · Brisbane, US
• Xiaodong Wang · Zhejiang, CN
• Malgorzata Wanska · Camarillo, US
• Kevin Yang · San Gabriel, US
• Wen-Chen YEH · Belmont, US

Key dates

• Filing date: Nov 3, 2017
• Grant date: Jun 29, 2021
• Expiry date: Jan 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.