Small molecule MDM2 protein degraders

US11046703B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Angelo Aguilar · Ann Arbor, US
• Yangbing Li · Beijing, CN
• Jiuling Yang · Ann Arbor, US
• Donna McEachern · Ann Arbor, US

Key dates

• Filing date: Oct 7, 2019
• Grant date: Jun 29, 2021
• Expiry date: Oct 7, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds represented by Formula I: wherein R1a, R1b, R2a, R2b, R3a, R3b, R4, A, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat cancer or any other disease, condition, or disorder that is responsive to degradation of MDM2 protein.