Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells

US11046724B2 · kind B2 · utility

Inventors

• Pui-Kwong Chan · Saginaw, US
• May Sung Mak · Hong Kong, CN
• Yun Wang · Dunedin, NZ

Key dates

• Filing date: Feb 26, 2019
• Grant date: Jun 29, 2021
• Expiry date: Feb 26, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/0005
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.