Filamentous fungal host
US11046736B2 · kind B2 · utility
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25Claims
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Key dates
| Filing date | Jul 19, 2017 |
| Grant date | Jun 29, 2021 |
| Priority date | — |
| Expiry date | May 6, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y302/01003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising and expressing a mutated ireA gene or a homologue thereof encoding a modified IreA polypeptide or a homologue thereof, said modified IreA polypeptide or homologue thereof comprising amino acid substitutions in 5 positions corresponding to positions 81 and 84 in the Aspergillus niger IreA amino acid sequence shown in SEQ ID NO:16, as well as methods of producing a polypeptide of interest in said cells and methods for constructing said cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.