P53-BAD fusion proteins

US11046740B2 · kind B2 · utility

Assignee

• University of Utah Research Foundation · US

Inventors

• Carol Lim · Salt Lake City, US
• Phong Lu · Salt Lake City, US

Key dates

• Filing date: May 16, 2019
• Grant date: Jun 29, 2021
• Expiry date: May 16, 2039

Classification

• Technology area (CPC —): General

Abstract

Disclosed are peptides comprising a p53 peptide and a BH3-only protein. In some aspects, wherein the BH3-only protein is BAD, BID, BIM, NOXA. Disclosed are nucleic acid sequences comprising a sequence capable of encoding a p53 peptide operably linked to a nucleic acid sequence capable of encoding a BH3-only protein. Disclosed are nucleic acid sequences comprising a sequence capable of encoding one or more of the peptides disclosed herein. Disclosed are vectors comprising a nucleic acid sequence, wherein the nucleic acid sequence is capable of encoding one or more of the peptides disclosed herein. Also disclosed are methods of using the disclosed peptides, nucleic acid sequences, and vectors.