Peptide mimotopes of the CD3 T-cell co-receptor epsilon chain and uses thereof

US11046745B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE
• JPT Peptide Technologies GmbH · DE

Inventors

• Ugur Sahin · Mainz, DE
• Laura Marie Kring · Munich, DE
• Markus Fiedler · Bodenwerder, DE
• Matin Daneschdar · Budenheim, DE
• Hans-Ulrich Schmoldt · Darmstadt, DE
• Ulf Reimer · Berlin, DE
• Karsten Schnatbaum · Berlin, DE

Key dates

• Filing date: Jul 14, 2015
• Grant date: Jun 29, 2021
• Expiry date: Sep 3, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/7051
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3ε). These molecules compete with CD3ε for binding to a CD3ε binding domain. e.g. a CD3ε binding domain of an antibody, and are capable of detecting antibodies against CD3ε. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3ε antibody purification and the detection of anti-CD3ε antibodies in biological samples.