Patent · US Active

Recombinant algal microorganisms having increased lipid production, and methods of making and using the same

US11046979B2 · kind B2 · utility

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1References
23Claims
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Key dates

Filing dateJul 22, 2019
Grant dateJun 29, 2021
Priority date—
Expiry dateJul 22, 2039

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y402/01017
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention provides a mutant algal microorganism that has a mutation that causes attenuated expression of TrifuncB and/or TrifuncA and as a result produces more lipids than a control algal microorganism. The mutant algal microorganism can further include a mutation in a gene encoding a peroxisomal beta-oxidation pathway protein, such as an ACO1 or PXA1 gene, or a glyoxylate pathway protein, such as an ICL1 gene, that results in attenuated expression and further increased lipid production. Furthermore, provided herein are methods of producing lipids using the mutant algal microorganisms and methods of making the mutant microorganisms.

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