Method for controlling the mass filter in a hybrid IMS/MS system

US11047828B2 · kind B2 · utility

Inventors

• Oliver Räther · Lilienthal, DE
• Markus Lubeck · Bremen, DE

Key dates

• Filing date: Apr 2, 2020
• Grant date: Jun 29, 2021
• Expiry date: Apr 2, 2040

Classification

• Technology area (CPC H): Electricity
• CPC primary: H01J49/4215
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides a method for acquiring as many fragment mass spectra of selected substances, e.g. proteins, of complex mixtures, as possible using a hybrid mass spectrometric system which comprises an ion source, an ion mobility separator, a mass filter, a fragmentation cell, and a mass analyzer. The fragment mass spectra are used for identifying the substances by their fragment mass spectra. The invention proposes to control the dwell time of the mass filter and to adapt the dwell time to the length of the ion mobility signal in a mass-mobility map.