Sustained-release injectable formulation

US11052043B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Michael Friedman · Jerusalem, IL
• Amnon Hoffman · Jerusalem, IL
• Eran Lavy · Modiin-Maccabim-Reut, IL

Key dates

• Filing date: Mar 28, 2012
• Grant date: Jul 6, 2021
• Expiry date: Oct 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A composition which comprises a biologically active agent and a polymer that exhibits a reverse thermal gelation at a physiological temperature, in a carrier, and in which the active agent is in an undissolved form is disclosed herein. Further disclosed herein are methods utilizing the compositions for treating subjects, including non-human subjects, as well as kits for preparing and using a composition. The composition is preferably a sustained release formulation, and is particularly useful for treating animals, where single-dose treatment is desired.