Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide

US11052053B2 · kind B2 · utility

Assignee

• Evonik Operations GmbH · DE

Inventors

• Roland Brock · Kalkar, DE
• Rike Nabbefeld · Cologne, DE
• Silko Grimm · Roßdorf, DE
• Anne Benedikt · Frankfurt, DE
• Andrea Engel · Birmingham, US
• Alexander Henrik Baron van Asbeck · Nijmegen, NL
• Jürgen Dieker · Darmstadt, DE

Key dates

• Filing date: Apr 24, 2019
• Grant date: Jul 6, 2021
• Expiry date: Apr 24, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/906
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nanoparticle includes a core. The core includes a bio-resorbable polyester and a hydrophilic polymer. The hydrophilic polymer is a portion of the bio-resorbable polyester or a separate polymer. An acylated human lactoferrin-derived peptide is coated onto the core. The acylated human lactoferrin-derived peptide is a peptide with the amino acid sequence SEQ ID NO. 1: KCFQWQRNMRKVRGPPVSCIKR or an amino acid sequence, which does not differ by more than 8 amino acid positions from the sequence SEQ ID NO: 1. The N-terminus of the human lactoferrin-derived peptide is acylated with a C16-monoacyl group.