Patent · US Active

Formulation for bispecific T-cell engagers (BiTEs)

US11052128B2 · kind B2 · utility

0Cited by

3References

9Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Carsten Olbrich · Berlin, DE
Thomas Bunte · Berlin, DE
Jonas Winter · Berlin, DE
Jorg Peters · Düsseldorf, DE
Thomas TRILL · Berlin, DE

Key dates

Filing date	Nov 5, 2013
Grant date	Jul 6, 2021
Priority date	—
Expiry date	Jun 30, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/622
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.