Use of car and bite technology coupled with an SCFV from an antibody against human thymidine kinase 1 to specifically target tumors
US11052138B2 · kind B2 · utility
2Cited by
13References
6Claims
0Family size
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Key dates
| Filing date | Sep 5, 2018 |
| Grant date | Jul 6, 2021 |
| Priority date | — |
| Expiry date | Oct 5, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A nucleic acid encoding a chimeric antigen receptor (CAR) comprising a single-chain variable fragment (scFv) operatively linked to a signaling domain that polarizes a macrophage to an M1 macrophage; wherein the nucleic acid is operatively linked to a macrophage specific promoter; and wherein the scFv is specific for a human antigen. Monocytes or macrophages comprising such a nucleic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.