Tangential flow filtration based protein refolding methods
US11053278B2 · kind B2 · utility
2Cited by
5References
10Claims
0Family size
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Key dates
| Filing date | Dec 5, 2018 |
| Grant date | Jul 6, 2021 |
| Priority date | — |
| Expiry date | Dec 5, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.