Preparation method of water-soluble phytosterol nano-dispersion system with intestinal targeted release function
US11058693B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2020 |
| Grant date | Jul 13, 2021 |
| Priority date | — |
| Expiry date | Aug 24, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5169
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention discloses a method for preparing a water-soluble phytosterol nano-dispersion system with intestinal targeted release function, which comprises the following steps: preparing a phytosterol solution; preparing an ethanol aqueous solution containing pectin; then adding zein to obtain a zein pectin solution; mixing the phytosterol solution and the zein pectin solution by means of ultrasonic treatment to obtain a nanoparticle dispersion liquid; rotavaping the nano-particle dispersion liquid to remove ethanol and water to obtain a zein/pectin loaded phytosterol nano-dispersion system. In this invention, not only an ultrasonic method and an anti-solvent method are adopted, but also a pectin component is added with zein as an entrapping agent, which ensures an effective entrapping of phytosterol by zein while further facilitating to form a more compact interface structure and improving a stability of the nano-dispersion system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.